Search results for "Macromolecular prodrugs"

showing 3 items of 3 documents

Calorimetric investigation of the interaction between a macromolecular prodrug of diflunisal and human platelets

1995

The thermal effect due to the interaction between human platelets and α,β poly(N-hydroxy-ethyl)-DL-aspartamide (PHEA) or the PHEA-Diflunisal conjugate was measured by the calorimetric technique at 25°C. The experimental data confirm that PHEA is a biocompatible macromolecule and that its conjugate influences the physiological activity of human platelets.

Macromolecular prodrugsStereochemistryChemistryThermal effectBiophysicsmedicineDiflunisalPlateletProdrugIn vitroMacromoleculemedicine.drugConjugateJournal of thermal analysis
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Macromolecular Prodrugs Based on Synthetic Polyaminoacids: Drug Delivery and Drug Targeting in Antitumor Therapy

2011

In the last twenty years a depth study on potential pharmaceutical applications of synthetic polymers at proteinlike structure as carrier for macromolecular prodrug production has been performed in academia and in industry. In particular α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA), α,β-polyaspartylhydrazide (PAHy), poly(glutamic acid) (PGA), poly(aspartic acid) (PAA) and polylysine (PLL) have been extensively studied in this field. In the present review, the use of PHEA, PAHy, PGA as starting materials to prepare macromolecular prodrugs is reported and drug delivery and targeting aspects have been considered.

Macromolecular prodrugsStereochemistryMacromolecular SubstancesAntineoplastic AgentsGeneral MedicineGlutamic acidCombinatorial chemistryAntitumor therapyαβ-poly(N-2-hydroxyethyl)-DL-aspartamideαβ-polyaspartylhydrazide poly(glutamic acid) carrierchemistry.chemical_compoundanticancer drugsDrug Delivery SystemschemistryTargeted drug deliverySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoPolylysineDrug DiscoveryAspartic acidDrug deliveryAnimalsHumansProdrugsAmino Acids
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Structure and properties of pharmacologically active polymers

1975

Although the concept of using pharmacologically active macromolecular compounds as drugs is still regarded with much skepticism for both theoretical and practical reasons, interest in this field has grown in recent years because of the opportunity to take advantage of the specific properties of polymeric materials. For low molecular weight drugs, changes in structure often lead to a loss of specific activity. On the other hand, the properties of macromolecular drugs depend on the structure of the polymer used and this can be varied over a wide range by the incorporation of comonomer units, by the application of polymer-analogous reactions, or by related structural changes. A new model is pr…

chemistry.chemical_classificationchemistry.chemical_compoundPolymer-drug conjugateschemistryMacromolecular prodrugsComonomerGeneral EngineeringOrganic chemistryBiological activityPolymerMacromolecular CompoundsCombinatorial chemistryMacromoleculeJournal of Polymer Science: Polymer Symposia
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